他汀类药物应用与胰腺癌的风险一项基于临

Statinuseandriskofpancreaticcancer:Resultsfromalarge,clinic-basedcase-controlstudy

EJWalker,AHKo,EAHolly,PMBracci

Abstract

Background:Statinsarecholesterol-loweringmedicationswithpleiotropiceffects,includingalterationsingrowthsignaling,aswellasimmunomodulatoryandanti-inflammatoryeffectsthatmayaltercancerrisk.Evidencefrompreviousepidemiologicstudiesisinconsistentaboutwhetherstatinuseisassociatedwithareducedriskofpancreaticcancer(PC).

Methods:PatientswithconfirmeddiagnosesofPC(cases)wererecruitedfrommedicalandsurgicaloncologyclinics,withcontrols(frequency-matchedbysexandage)recruitedfromgeneralmedicineclinics,atahigh-volumeacademicmedicalcenterovera6-yearperiod(-).Directinterviewswereconductedwithanepidemiologicalriskfactorquestionnairecoveringtopicssuchasmedicalhistory,lifestylefactors,andmedicationusage.Adjustedmultivariablelogisticregressionwasusedto







































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